My research program seeks to understand how the functional organization of the brain supports human cognition and consciousness, and how this organization breaks down in the disordered brain. My work combines psychological theory, neuroimaging, and research of brain-injured and anesthesized patients, and translates this knowledge to develop clinically applicable neuroimaging measures. Additionally, my work explores the medico-ethical and societal implications of such applications, to build ethical guidelines for their translation to clinical settings.
Naci, L., Graham, M., Owen, A. M. Weijer, C. Covert narrative capacity: A cross-section of the preserved mental life in patients thought to lack consciousness. Annals of Clinical and Translational Neurology. Under Review.
Sinai L., Owen AM, Naci L*. Mapping preserved real-world cognition in brain-injured patients. Frontiers in Bioscience. In Press. *Senior Author
Gibson, R. M., Chennu, S., Fernández-Espejo, D., Naci. L., Owen, A. M, Cruse, D. Somatosensory attention identifies both overt and covert awareness in disorders of consciousness. Annals of Neurology. In Press. doi: 10.1002/ana.24726. [Epub ahead of print].
Naci, L., Sinai, L, Owen, A. M. Detecting and interpreting conscious experiences in behaviorally non-responsive patients. NeuroImage. In Press. pii: S1053-8119(15)01096-4. doi: 10.1016/j.neuroimage.2015.11.059. [Epub ahead of print].
Owen, A. M., Naci, L. Decoding thoughts in behaviourally non-responsive patients. In Sinnott-Armstrong (Ed). Finding Consciousness. Oxford University Press. In Press.
Peterson, A., Cruse, D., Naci, L., Weijer, L., Owen, M. A. Risk, Diagnostic Error, and The Clinical Science of Consciousness. NeuroImage: Clinical. 2015; 7: 588–597. Download
Naci, L., Taylor, K. I., Cusack, I., Tyler, L. K. (2015) Are the senses enough for sense? Early high-level feedback shapes our comprehension of multisensory objects. In S. Zhuanghua and H. J. Müller (Eds.) Multisensory perception and action: psychophysics, neural mechanisms, and applications. eBook. Frontiers Research Topics.
Graham, M., Weijer, C., Cruse, D.,Fernandez-Espejo, D., Gofton, T., Gonzalez-Lara, L., Lazosky, A., Naci, L., Norton, L., Peterson, A., Speechley, N. K., Young,B.,, Owen, M. A. An Ethics of Welfare for Behaviourally Non-responsive Patients with Covert Awareness. AJOB Neuroscience In Press.
MacDonald, A., Naci, L., MacDonald, P., Owen, A. M. Anesthesia and neuroimaging: Investigating the neural correlates of unconsciousness. TICS. 2015;19(2): 100–107. Download
Naci, L., Cusack, R., Anello, M., Owen, A. M. A common neural code for similar conscious experiences in different individuals. PNAS. 2014;111(39):14277–82. Download Featured on Macleans, Science, and Nature.
Owen, A. M., Naci, L. Decoding thoughts in disorders of consciousness. In M. Monti and W. G. Sannita (Eds.) Brain Function and Responsiveness in Severe Disorders of Consciousness. Springer. In Press.
Peterson, A., Norton, L., Naci, L., Owen, A. M., Weijer, C. Toward a Science of Brain Death. Am J Bioeth. 2014;14(8):29-31. Download
Weijer, C., Peterson, P., Webster, F., Graham, M., Cruse, D., Fernández-Espejo, D., Gofton, T., Gonzalez-Lara, L. E., Lazosky, A., Naci, L., Norton, L., Speechley, K., Young B., Owen, A. M. Ethics of neuroimaging after serious brain injury. BMC Medical Ethics 2014; 15, 41. Download
Naci, L., Owen, A. M. Making every word count for vegetative patients. JAMA Neurology. 2013; 70(10), 1235-41. Download or Read it for free at the Journal of the American Medical Association. INTERNATIONAL MEDIA COVERAGE.
Guger, C., Noirhomme, Q., Naci, L., Real, R., Lugo, Z., Veser, S., Sorger, B., Quitadamo, L., Lesenfants, D., Risetti, M., Formisano, R., Toppi, J., Astolfi, L., Emmerling, T., Erlbeck, H., Monti, M. M., Kotchoubey, B., Bianchi, L., Mattia, D., Goebel, R., Owen, A. M., Pellas, F., Müller-Putz, G., Kübler, A. Brain-computer interfaces for coma assessment and communication. Emerging Theory and Practice in Neuroprosthetics; ed. Ganesh R Naik, IGIGLOBAL Press 2013.
Naci, L., Cusack, R., Jia, Z., V., Owen, M. A. The brain’s silent messenger – using selective attention to decode human thought for brain-based communication. J Neurosci 2013; 33(22), 9385–9393. Download. Featured on PSYCHOLOGY PROGRESS.
Peterson, A., Naci, L., Weijer, C., Owen A. M. A principled argument, but not a practical one. AJOB Neuroscience 2013; 4(1), 52–53. Download
Peterson, A., Naci, L., Cruse, C., Fernández-Espejo, E., Graham, M., Weijer, C., Owen, A. O. Assessing decision making capacity in the disorder of consciousness patient. AJOB Neuroscience 2013; 4(4), 3-14. Download
Graham, M., Weijer, C., Peterson, A., Naci, L., Cruse, C., Fernández-Espejo, E., Owen, A. O. Acknowledging awareness: informing families of individual research results for patients in the vegetative state. J Med Ethics. Published Online First: [please include 30/07/2014] doi:10.1136/medethics-2014-102078. Download
Naci, L., Monti, M. M., Cruse, D., Sorger, B., Rainer, G., A., Kotchoubey, B., Kubler. A, Owen, A. M. Brain computer interfaces for communication with non-responsive patients. Ann Neurol 2012; 72(3), 312–23. Download
Naci, L., Cusack, R., Taylor, K., Tyler, L. K. Are the senses enough for sense? Recurrent high-level feedback shapes our comprehension of multisensory objects. Front Integr Neurosci 2012. Download
Cusack, R., Veldsman, M., Naci, L., Mitchell, D. J., Linke, A. Seeing different objects in different ways: measuring ventral visual tuning to sensory and semantic features with dynamically adaptive imaging. Hum Brain Mapp 2012; 33(2), 387–97. Download
Covington, M., He, C., Brown, C., Naci, L., Brown, J. How complex is that sentence? A proposed revision of the Rosenberg and Abbeduto D-Level scale. Research Report, 2006. Artificial Intelligence Center, University of Georgia. Download
Covington, M., He, C., Brown, C., Naci, L., McClain, T., Fjordbak, B., Semple, J., Brown, J. Schizophrenia and the structure of language: The linguist’s view. Schizophrenia Research 2005; 77(1), 85–98.
Naci, L. Software to measure rambling, cognitive difficulty and degree expression in schizophrenic speech. Artificial Intelligence Center, University of Georgia. Download